London: Drinking cherry juice concentrate may help patients beat gout, according to new research.
Tart cherries have long been researched for their association with pain relief ranging from gout and arthritis joint pain to exercise-related muscle pain, researchers said.
The study is the first to report consumption of Montmorency tart cherries caused changes in uric acid metabolism, which can have an impact on joint pain.
The study also detected increases in specific anthocyanin compounds in the bloodstream after consuming tart cherries.
In the study, Montmorency tart cherry juice reduced blood levels of uric acid and C-reactive protein, a measure of inflammation, researchers said.
High levels of uric acid are linked to gout, a form of arthritis that can cause severe attacks of intense pain and swelling (inflammation) in various joints, including the big toe and other joints in the legs and arms.
A research team led by Dr Glyn Howatson with PhD student Phillip Bell at Northumbria University in the UK gave 12 healthy participants (average age 26 years) two doses of Montmorency tart cherry juice concentrate: about 1 ounce (30 ml) of the juice concentrate mixed with 100 ml of water (equivalent to 90 whole Montmorency tart cherries) or 2 ounces (60 ml) of juice concentrate mixed with 100 ml of water.
The researchers used a single blind, two-phase, randomised, cross-over design to identify the bioavailability of anthocyanins following the consumption of these two different doses.
There was a washout period of at least 10 days between the phases. Each phase was comprised of two days drinking the tart cherry juice concentrate twice a day - in the morning and just before dinner.
The researchers collected blood and urine samples from the participants immediately before and at numerous intervals for 48 hours after the tart cherry juice was consumed.
The results supported the researchers' hypothesis: blood levels of uric acid and C-reactive protein were reduced and urinary uric acid was increased following both doses of the tart cherry juice.
The magnitude of the change was independent of the dose given; that is, the 30 ml of the juice was just as effective as 60 ml, researchers said.
"We have been investigating Montmorency tart cherries for several years because they're a unique fruit with a high concentration of anthocyanins," said co-author Howatson.
A second study by researchers from the University of Michigan found that the antioxidant capacity in the blood was elevated after eating whole frozen Montmorency tart cherries (45 or 90 cherries), and remained elevated even 12-hours after eating the 90 cherries.
Similar to the Howatson team in the UK, they also observed tart cherry anthocyanin metabolites in the blood and urine with both doses of the whole tart cherries.
The research was published in the Journal of Functional Foods.