New Delhi: A positive association between fish oil supplements and cognitive functioning as well as differences in brain structure between users and non-users of fish oil supplements has been found by researchers at Rhode Island Hospital`s Alzheimer`s Disease and Memory Disorders Center.
The findings suggest possible benefits of fish oil supplements on brain health and aging.
The study included 819 individuals, 117 of whom reported regular use of fish oil supplements before entry and during study follow-up. The researchers compared cognitive functioning and brain atrophy for patients who reported routinely using these supplements to those who were not using fish oil supplements.
Lori Daiello, PharmD, a research scientist at the Rhode Island Hospital Alzheimer`s Disease and Memory Disorders Center, who led the study, reported that compared to non-users, use of fish oil supplements was associated with better cognitive functioning during the study. However, this association was significant only in those individuals who had a normal baseline cognitive function and in individuals who tested negative for a genetic risk factor for Alzheimer``s Disease known as APOE4. This is consistent with previous research.
The unique finding, however, is that there was a clear association between fish oil supplements and brain volume. Consistent with the cognitive outcomes, these observations were significant only for those who were APOE4 negative.
"In the imaging analyses for the entire study population, we found a significant positive association between fish oil supplement use and average brain volumes in two critical areas utilized in memory and thinking (cerebral cortex and hippocampus), as well as smaller brain ventricular volumes compared to non-users at any given time in the study. In other words, fish oil use was associated with less brain shrinkage in patients taking these supplements during the ADNI study compared to those who didn``t report using them," said Daiello.
"These observations should motivate further study of the possible effects of long-term fish oil supplementation on important markers of cognitive decline and the potential influence of genetics on these outcomes," added Daiello.
The results were presented at the recent International Conference on Alzheimer`s Disease, in Paris, France.