London: High levels of phosphates may add more "pop" to sodas and junk food but they also speed up aging, research says.
They may also increase the prevalence and severity of age-related complications, such as chronic kidney disease and cardiovascular calcification, and can also induce severe muscle and skin atrophy, it added.
"Humans need a healthy diet and keeping the balance of phosphate may be important for a healthy life and longevity," said M Shawkat Razzaque from the Department of Medicine, Infection and Immunity at the Harvard School of Dental Medicine.
To make this discovery, Razzaque and his colleagues examined the effects of high phosphate levels in three groups of mice.
The first group of mice was missing a gene (klotho), which when absent, causes mice to have toxic levels of phosphate in their bodies. These mice lived eight to 15 weeks.
The second group of mice was missing the klotho gene and a second gene (NaPi2a), which when absent at the same time, substantially lowered the amount of phosphate in their bodies. These mice lived up to 20 weeks.
The third group was like the second group, missing both the klotho and NaPi2a genes, except they were fed a high-phosphate diet. All of these mice died by 15 weeks, like those in the first group.
This suggests that phosphate has toxic effects in mice, and may have a similar effect in other mammals, including humans, a Harvard School release said.
"Soda is the caffeine delivery vehicle of choice for millions of people worldwide, but comes with phosphorous as a passenger," said Gerald Weissmann, editor-in-chief of the FASEB Journal, which published the findings.
"This research suggests that our phosphorous balance influences the aging process, so don`t tip it," he added.