Researchers identify new culprit type 2 diabetes gene!

Using the gene editing technology called CRISPR and other sophisticated scientific tools, the researchers identified this gene, ACSL5.

Zee Media Bureau

New York: Scientists have identified a new gene which they claim is a culprit for type 2 diabetes.

Using the gene editing technology called CRISPR and other sophisticated scientific tools, the researchers identified this gene, ACSL5.

They believe that because this gene ACSL5, codes for a protein that regulates how the body recognises insulin, that protein may represent an important target for future treatments for the disease.

"Type-2 diabetes is increasingly common, with an impact on millions of people," said study leader Struan Grant from The Children's Hospital of Philadelphia (CHOP) in the US.

"But it has complex causes, involving multiple genes and environmental influences, and we are still learning the details of its complicated biology. Our goal in investigating these biological functions is to develop more effective therapies," Grant said.

Because the the gene codes for the enzyme, acyl CoA synthesase 5, that plays a role in lipid metabolism, developing drugs to act on this enzyme might help patients with Type-2 diabetes by increasing their sensitivity to insulin - an underlying issue in the disease,

However, much remains to be learned about the action of the newly identified culprit gene, the authors cautioned.

The new research sheds light on some of the twists and turns of applying gene discovery to help unravel a complex disease.

The study has been published in the journal Diabetologia.

 

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