Washington: Although orangutans and humans are more distantly related, some regions of our genomes are more alike than those of our closest living relative, the chimpanzee, suggests a new study.
The fossil record helped to establish evolutionary relationships and estimate divergence times of the primate branch leading to humans, but not until the advent of genome sequencing technology has it been possible to learn more detail about speciation times, genetic and phenotypic divergence times, and the genetic variation present in common ancestor species.
With the addition of the orangutan to the collection of sequenced primate genomes, an international group of scientists led by Mikkel Schierup and Thomas Mailund of Aarhus University in Denmark set out to shed light on these questions in primate evolution.
"There remains signals of the distant past in DNA," said Mailund, "and our approach is to use such signals to study the genetics of our ancestors."
When a population "splits", the genetic variation they each inherit from the common ancestor will change over time as the populations diverge, possibly giving rise to two different species.
Because humans, chimps, and orangutans all have a common ancestor, it is possible that humans and orangutans may still share genetic variants that were later lost in more closely related primates.
Mailund and colleagues employed a mathematical framework to find regions of the orangutan genome where humans and orangutans are more closely related than humans and chimpanzees as a result of a phenomenon called incomplete lineage sorting (ILS). ILS can reveal information about the time of speciation events, as well as the genetic diversity of the ancestral species.
The study found ILS with orangutan and chimp in approximately 1 percent of the human genome.
"In about 0.5 percent of our genome, we are closer related to orangutans than we are to chimpanzees," Mailund said, "and in about 0.5 percent, chimpanzees are closer related to orangutans than us."
The study has been published online in Genome Research.