Six-months old treated for rare liver disorder

Bleeding at regular intervals from under his skin, in his brain and kidneys since birth, six-month old Tavish Jain can now have some relief.

Last Updated: Sep 22, 2010, 22:31 PM IST

New Delhi: Bleeding at regular intervals
from under his skin, in his brain and kidneys since birth,
six-month old Tavish Jain can now have some relief.

Doctors have finally provided him relief from his
condition by transplanting a small portion of his mother`s
liver. They claim Jain was the world`s youngest child on whom
such a procedure was conducted.

Hailing from Mumbai, Tanvish`s condition scared his
parents a lot. He was suffering from factor VII deficiency (a
factor normally produced in the liver which is essential for
normal clotting of blood) since birth.

"He had bruises on skin and suffered many episodes of
bleeding in the gums, kidney, gastrointestinal area and in the
brain. We were under constant fear that we might lose him.
Doctors told us that Tavish`s condition was incurable and
eventually fatal," Bijal, his father said.

Tanvish`s condition needed frequent hospital admission
to prevent fatal bleeding.

"He was administered injections to prevent bleeding
which cost around a lakh. But this was a routine thing every
month," he said.

The parents saw a ray of hope when he was referred to
Medanta Medcity in Gurgaon, founded by eminent cardiac surgeon
Dr Naresh Trehan.

"Tanvish is the youngest child in the world to be
successfully treated for factor VII deficiency with liver
transplant. It was a huge challenge as we were trying the
treatment for such a condition on a six-months old child who
weighed too less to undergo such a complicated surgery," Dr A
S Soin, Chief Surgeon and Chairman of Medanta Institute of
Liver Transplantation, said.

"With his weight he needed only 150 g of liver and the
smallest removable portion of his mother`s liver was 300 g. So
we had to prune it further, which left many raw surfaces on it
making it more liable to bleeding. Additional risks included
administering him factor VII so that there was no excess
clotting or bleeding," he said.

Finally on September 31, a team of team of 25 liver
surgeons and anaesthetists could successfully accomplish this
daunting operation which took 12 hours.

Dr Neelam Mohan, Chief Liver Transplant Physician and
Director of Paediatric Gastroenterology and Hepatology, said
that factor VII deficiency which occurs one in 5,00,000
births, has almost always been fatal in the past due to
difficulties in diagnosing and treating it.

"Patients would die either from sudden rapid bleeding of
undiagnosed cause or be faced with the impossible situation of
taking factor VII injections for life, " she said.

Dr Trehan, Chairman and Managing Director, Medanta said,
"Every year thousands of children in India would be dying of
factor VII deficiency and our successful treatment of this
disorder by liver transplant has given a ray of hope for these
patients."

-PTI