Stem cells that ``fool immune system`` may help fight cancer
Washington: A vaccine containing stem cells could help provide a vaccination against colon cancer, say scientists from the United States and China.
In the study published in Stem Cells, boffins revealed the potential for human stem cells to provide a vaccination against colon cancer.
The discovery, led by experts in immunology, Dr. Bei Liu and Dr. Zihai Li, builds upon a century old theory that immunizing with embryonic materials may generate an anti-tumour response. However, this theory has never before been advanced beyond animal research so the discovery that human stem cells are able to immunize against colon cancer is both new and unexpected.
"This finding potentially opens up a new paradigm for cancer vaccine research," said Dr. Zihai Li.
"Cancer and stem cells share many molecular and biological features. By immunizing the host with stem cells, we are able to ``fool`` the immune system to believe that cancer cells are present and thus to initiate a tumor-combating immune program,” the expert added.
The research is the first of its kind to implicate the role of human stem cells in vaccinating against colon cancer, and represents collaboration between the prestigious laboratories of Dr. Zihai Li and stem cell expert Dr. Renhe Xu at the University of Connecticut Stem Cell Institute.
The team vaccinated laboratory mice with human embryonic stem (hES) cells and discovered a consistent immune response against colon cancer cells. The team witnessed dramatic decline in tumor growth within the immunized mice. This revealed that immunized mice could generate a strong anti-tumour response through the application of hES cells.
The team also discovered that while natural embryonic stem cells are able to provide a response, artificially induced pluripotent stem cells (iPSC) are not. This is significant as it challenges the theory that iPSC are the same as hES cells and may replace them at the forefront of stem cell research.
"Although we have only tested the protection against colon cancer, we believe that stem cells might be useful for generating an immune response against a broad-spectrum of cancers, thus serving as a universal cancer vaccine," " concluded Dr. Bei Liu.
More from India
More from World
More from Sports
More from Entertaiment
- Dadri lynching: Is Kejriwal spreading poison between Hindus and Muslims?
- Lalu Prasad calls beef eating people uncultured
- Why did Indrani Mukerjea attempt suicide?
- Dadri lynching: Locals stop Arvind Kejriwal from entering Bisara village
- Muslims asked to sprinkle cow urine on body in order to be part of Garba festivities
- Sonia begins Bihar polls campaining; accuses PM Modi of 'narrow-mindedness'
- Salman Khan’s ‘Prem Ratan Dhan Payo’ trailer creates a record!
- Indrani Mukerjea's FSL report rules out drug overdose, says no chemicals found in stomach wash
- Lynching case in Dadri: Rahul meets victim Iqlakh's family, says touched by people's desire to maintain harmony
- Muslims banned from Garba in Gujarat's Mandvi; Hindus asked to sprinkle cow urine on themselves