11 new `risk genes` tied to Alzheimer`s discovered
Washington: Researchers have identified 11 new regions of the genome that contribute to late-onset Alzheimer's disease, doubling the number of potential genetics-based therapeutic targets to investigate.
In 2011, the world's four largest research consortia on the genetics of Alzheimer's disease joined efforts to discover and map the genes that contribute to Alzheimer's, forming the International Genomics of Alzheimer's Project (IGAP).
The team collected genetic information from 25,500 Alzheimer's disease patients and 49,038 controls from 15 countries to perform this two-stage meta-analysis that resulted in the discovery of 11 new genes in addition to those already known, and the identification of 13 other genes, yet to be validated.
Margaret A. Pericak-Vance, Ph.D., the Dr. John T. Macdonald Foundation Professor of Human Genomics and Director of the John P. Hussman Institute for Human Genomics at the Miller School, and Lindsay A. Farrer, Ph.D., from Boston University, led the analysis teams for the American Alzheimer's Disease Genetics Consortium, which includes nearly all of the nation's researchers working on the genetics of Alzheimer's, as well as many investigators and resources of the 29 federally funded Alzheimer's Disease Centers.
Several of the genes the researchers identified confirmed known biological pathways of Alzheimer's disease, including the role of the amyloid (SORL1, CASS4) and tau (CASS4, FERMT2) pathways. Newly discovered genes involved in the immune response and inflammation (HLA-DRB5/DRB1, INPP5D, MEF2C) reinforced a pathway implied by previous work (on CR1, TREM2).
Additional genes related to cell migration (PTK2B), lipid transport and endocytosis (SORL1) also were confirmed, and new hypotheses emerged related to hippocampal synaptic function (MEF2C, PTK2B), the cytoskeleton and axonal transport (CELF1, NME8, CASS4), as well as myeloid and microglial cell functions (INPP5D).
One of the more significant new associations was found in the HLA-DRB5/DRB1 region, one of the most complex parts of the genome, which plays a role in the immune system and inflammatory response. It also has been associated with multiple sclerosis and Parkinson's disease, suggesting that the diseases where abnormal proteins accumulate in the brain may have a common mechanism involved, and possibly a common drug target.
The study has been published in journal Nature Genetics.
More from India
More from World
More from Sports
More from Entertaiment
- Salman Khan attends sister Arpita's wedding reception in Mandi
- I eat beef, can somebody stop me?: Kiren Rijiju hits back at Naqvi
- Zee Media's mega survey on Modi govt
- Delhi: Visually impaired boy scores 91.4% in CBSE 12th Board exams
- MP: 14-year-old boy works as bonded labour since 2009
- UP: Man chops off wife's nose, hair for dowry
- Zee Media Exclusive: The plight of yoga expert Tejaswi Sharma
- Woman denied flat in Mumbai for being a Muslim
- 4 Indians in Forbes' 100 most powerful women list
- BBV: What challenges lie ahead of Modi govt?
- DNA analysis of rising water crisis in India!
- Gujjar stir: HC asks Rajasthan govt to clear rail track, roads
- DNA: Delhi shop owners express their plight through Zee initiative 'My News'
- Watch: Zee Media mega survey on Modi govt- Part 2
- Gujjar stir: HC asks Rajasthan govt to clear rail track, roads- Part II
- Arpita-Aayush wedding reception: Salman Khan spreads love in Mandi, says `hum aapke hain`
- CBSE Class 10 Board Result 2015 (cbse.nic.in, cbseresults.nic.in) postponed?
- CBSE Class 10 Board Result 2015 to be announced today
- Check mahresult.nic.in for MSBSHSE Maharashtra Class 12 HSC Result 2015
- Maharashtra MSBSHSE HSC Result 2015 on mahresult.nic.in
- Rahul Gandhi takes a dig at one year of Modi govt, wishes 'happy birthday' to 'suit-boot ki sarkar'
- I was misquoted, says Kiren Rijiju on 'beef' remark
- mahresult.nic.in updated with MSBSHSE Maharashtra HSC Class XII Result 2015
- First look: Salman Khan steals thunder in `Bajrangi Bhaijaan`
- Manmohan Singh defends himself on 2G charge, slams Modi govt for 'carbon copy' schemes
- Sonia Gandhi 'unconstitutional authority' during UPA: PM Narendra Modi
- Reservation stir: Five percent job quota to Gujjars unlikely, hints Rajasthan govt
- Hours after attacking NDA govt, Manmohan Singh meets PM Narendra Modi
- Check cbse.nic.in, cbseresults.nic.in for CBSE Class 10 Result 2015
- CBSE (cbse.nic.in ) Class X results 2015: CBSE Class 10th Board results likely to be declared tomorrow on cbseresults.nic.in