Alzheimer`s and Parkinson`s may not share common genetic risk
Washington: Alzheimer and Parkinson disease do not appear to share a common genetic risk, a new study has revealed.
Researcher Valentina Moskvina, Ph.D., of the Cardiff University School of Medicine, Wales, United Kingdom, and colleagues, examined the genetic overlap between Parkinson disease (PD) and Alzheimer disease (AD).
Data sets from the United Kingdom, Germany, France and the United States were used to perform a combined genome-wide association analysis (GWA).
The GWA study of AD included 3,177 patients with AD and 7,277 control patients, and the GWA analysis for PD included 5,333 patients with PD and 12,298 control patients.
According to the study results, the gene-based analyses resulted in no significant evidence that supported the presence of loci (location of gene) that were associated with increased risk for both PD and AD.
The research concluded that loci that increase the risk of both the diseases are not widespread and that the pathological overlap could instead be `downstream` of the primary susceptibility genes that increase the risk of each disease.
The study is published in journal JAMA Neurol.