London: In a new study, scientists have tried to unlock the potential of retinoids to treat patients with acute myeloid leukemia (AML).
A retinoid called all-trans retinoic acid (ATRA), which is a vitamin A-derivative, is already used successfully to treat a rare sub-type of acute myeloid leukemia (AML), however this drug has not been effective for the more common types of AMLs.
In the new study Arthur Zelent and his colleagues at the ICR have shown that the key could be an antidepressant called tranylcypromine (TCP).
“Retinoids have already transformed one rare type of fatal leukemia into a curable disease. We``ve now found a way to harness these powerful drugs to treat far more common types of leukemia,” Zelent, senior author of the study, said.
“Until now, it’s been a mystery why the other forms of AML don’t respond to this drug. Our study revealed that there was a molecular block that could be reversed with a second drug that is already commonly used as an antidepressant. We think this is a very promising strategy, and if these findings can be replicated in patients the potential benefits are enormous,” he said.
ATRA works by encouraging the leukemia cells to mature and die naturally. The team thinks the failure of AML to respond to this drug may be due to genes that ATRA normally targets becoming switched off.
In their search for a drug that could be used to reboot the activity of ATRA, the team looked to an emerging area of research called epigenetics.
Epigenetic drugs do not target genes directly but instead target whether genes are switched on or off. They discovered that inhibiting an enzyme called LSD1, using TCP, could switch these genes on again and make the cancer cells susceptible to ATRA.
Along with collaborators at the University of Munster in Germany, the team have already started a Phase II clinical trial of the drug combination in acute myeloid leukemia patients.
“Both the retinoid ATRA and the antidepressant TCP are already available in the UK and off-patent, so these drugs should not be expensive for the health service,” Kevin Petrie, co-author of the study from ICR, said.
“AML remains very difficult to treat and sadly is often fatal, with rates of the disease projected to increase significantly as the population ages, so it is particularly pleasing to have identified this new treatment approach.
“Importantly, we believe these drugs are targeting only the cancer cells and leaving normal healthy cells largely untouched, so we are hopeful that they would have fewer side-effects for patients than standard drugs. We look forward to seeing the results of the clinical trials,” he said.
The study has been recently published in Nature Medicine.