Artery formation after heart attack discovered
Washington: Researchers from Yale School of Medicine and University College London (UCL) have uncovered the molecular pathway by which new arteries may form after heart attacks, strokes and other acute illnesses bypassing arteries that are blocked.
Arteries form in utero and during development, but can also form in adults when organs become deprived of oxygen - for example, after a heart attack.
The organs release a molecular signal called VEGF. Working with mice, the Yale-UCL team discovered that in order for VEGF-driven artery formation to occur, VEGF must bind with two molecules known as VEGFR2 and NRP1, and all three must work as a team.
The researchers examined mice that were lacking a particular part of the NRP1 molecule that transports VEGF and VEGFR2 to a signaling center inside blood vessel walls.
They observed that the internal organs of these mice contained poorly constructed arterial branches.
Further, the mice were unable to efficiently repair blood vessel blockage through the formation of new arteries.
"We have identified an important new mechanism that regulates VEGFR2 transport in vascular cells," corresponding author Michael Simons, professor of medicine and cell biology, and director of the cardiovascular research center at Yale School of Medicine said.
"This opens new therapeutic opportunities for developing drugs that would either stimulate or inhibit blood vessel formation - important goals in cardiovascular and anti-cancer therapies, respectively," he said.
The study appears in the journal Developmental Cell.