Cells found in front surface of the eye may cure blindness

Last Updated: Tuesday, November 20, 2012 - 20:30

London: Scientists have discovered specific cells in front surface of the eye that have stem cell properties and could lead to new procedures to cure blindness.

Researchers at the University of Southampton led by Professor Andrew Lotery found that cells called corneal limbal stromal cells, taken from the front surface of the eye have stem cell properties and could be cultured to create retinal cells.

This could lead to new treatments for eye conditions such as retinitis pigmentosa or wet age-related macular degeneration, a condition which is the common cause of loss of vision in older people.

The research suggested that using corneal limbus cells would be beneficial in humans as it would avoid complications with rejection or contamination because the cells taken from the eye would be returned to the same patient.

"This is an important step for our research into the prevention and treatment of eye conditions and blindness," Lotery said.

"We were able to characterise the corneal limbal stromal cells found on the front surface of the eye and identify the precise layer in the cornea that they came from. We were then successful in culturing them in a dish to take on some of the properties of retinal cells," Lotery said in a statement.

"We are now investigating whether these cells could be taken from the front of the eye and be used to replace diseased cells in the back of the eye in the retina. If successful this would open up new and efficient ways of treating people who have blinding eye conditions," Lotery added.

This is a promising discovery as the corneal limbus is one of the most accessible regions of the human eye and it represents 90 per cent of the thickness of the front eye wall.

Therefore cells could be easily obtainable from this area with little risk to the patient`s eye and sight, researchers said.

However, Lotery said more research is needed to develop this approach before they are used in patients.

The study was published in the British Journal for Ophthalmology.

PTI



First Published: Tuesday, November 20, 2012 - 20:30

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