Drug shows promise in busting Hepatitis C virus
Washington: Hepatitis C virus (HCV) infection affects about 4.1 million people in the United States alone and is the primary cause of liver cirrhosis and liver cancer. Current therapy against the infection is not particularly effective.
Daclatasvir, a direct acting antiviral (DAA) agent, targets one of the HCV proteins NS5A and causes the fastest viral decline, within 12 hours of treatment ever seen with anti-HCV drugs.
An interdisciplinary effort by mathematical modellers, clinicians and molecular virologists has revealed that daclatasvir has two main modes of action against HCV and also yields a new, more accurate estimate of the HCV half-life, the journal Proceedings of the National Academy of Sciences reports.
"Ultimately, our study will help design better DAA drug cocktails to treat HCV," said Loyola University Health System (LUHS) and Stritch School of Medicine (SSOM) mathematical modeller Harel Dahari, who co-led the study.
Dahari is one of five members of the Division of Hepatology at Loyola headed by Scott Cotler, who authored the study with Thomas Layden, HCV virologist Susan L. Uprichard and her doctoral graduate student Natasha Sansone, according to a Loyola statement.
"Daclatasvir not only blocks the synthesis of the viral RNA within infected cells but also secretion of infectious virus from the cells," said Dahari.
This prediction was confirmed in Uprichard`s lab using cultured liver cells that support the entire life cycle of HCV infection.
Download the all new Zee News app for Android and iOS to stay up to date with latest headlines and news stories in Politics, Entertainment, Sports, Technology, Business and much more from India and around the world.
More from India
More from World
More from Sports
More from Entertaiment
- Mumbai: Police arrests 4 schoolboys for raping classmate
- Haryana minister Anil Vij gets into spat with Fatehabad SP Sangeeta Kalia
- Panel discussion on Farooq Abdullah's controversial statement on PoK
- Watch: PM Narendra Modi's full speech in Parliament
- DNA: Heart-wrenching stories of Kashmiri pandits
- Tamasha movie review: Poignant and riveting; Ranbir's the master here!
- Kim Jong-Un issues bizarre diktat, asks North Korean men to copy his hairstyle, women to follow his wife
- Muslim man sends 'talaq' SMS to wife after learning about her gang-rape
- WATCH: Rare CCTV video of Ajmal Kasab and other terrorists of 26/11 Mumbai attacks
- Watch: PM Narendra Modi's speech in Parliament on Constitution debate