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How infections in liver and stomach can lead to cancer

Last Updated: Tuesday, June 12, 2012 - 16:18

Washington: Chronic inflammation of liver, colon or stomach, often caused by viral or bacterial infections, is one of the biggest risk factors for cancer in these organs.

Now, a new study from MIT has provided the most comprehensive look yet at how such infections provoke tissues into becoming cancerous.

The study tracked a variety of genetic and chemical changes in the livers and colons of mice infected with Helicobacter hepaticus, a bacterium similar to Helicobacter pylori, which causes stomach ulcers and cancer in humans.

The findings could help researchers develop ways to predict the health consequences of chronic inflammation, and design drugs to halt such inflammation.

“If you understand the mechanism, then you can design interventions,” said Peter Dedon, an MIT professor of biological engineering.

“For example, what if we develop ways to block or interrupt the toxic effects of the chronic inflammation?” he stated.

For the past 30 years, Steven Tannenbaum, a professor of biological engineering and chemistry and a senior author of the study, has led a group of MIT researchers dedicated to studying the link between chronic inflammation and cancer.

Inflammation is the body’s normal reaction to any kind of infection or damage, but when it goes on for too long, tissues can be damaged.

When the body’s immune system detects pathogens or cell damage, it activates an influx of cells called macrophages and neutrophils. These cells’ job is to engulf bacteria, dead cells and debris: proteins, nucleic acids and other molecules released by dead or damaged cells. As part of this process, the cells produce highly reactive chemicals that help degrade the bacteria.

“In doing this, in engulfing the bacteria and dumping these reactive chemicals on them, the chemicals also diffuse out into the tissue, and that’s where the problem comes in,” Dedon explained.

If sustained over a long period, that inflammation can eventually lead to cancer.

In the new MIT study, the researchers analyzed mice that were infected with H. hepaticus, which causes them to develop a condition similar to inflammatory bowel disease in humans. Over the course of 20 weeks, the mice developed chronic infections of the liver and colon, with some of the mice developing colon cancer.

Throughout the 20-week period, the researchers measured about a dozen different types of damage to DNA, RNA and proteins. They also examined tissue damage and measured which genes were turned on and off as the infection progressed. One of their key findings was that the liver and colon responded differently to infection.

In the colon, but not the liver, neutrophils secreted hypochlorous acid (also found in household bleach), which significantly damages proteins, DNA and RNA by adding a chlorine atom to them. The hypochlorous acid is meant to kill bacteria, but it also leaks into surrounding tissue and damages the epithelial cells of the colon.

The researchers found that levels of one of the chlorine-damage products in DNA and RNA, chlorocytosine, correlated well with the severity of the inflammation, which could allow them to predict the risk of chronic inflammation in patients with infections of the colon, liver or stomach.

Tannenbaum recently identified another chlorine-damage product in proteins: chlorotyrosine, which correlates with inflammation.

While these results point to an important role for neutrophils in inflammation and cancer, “we don’t know yet if we can predict the risk for cancer from these damaged molecules,” Dedon said.

Another difference the researchers found between the colon and the liver was that DNA repair systems became more active in the liver but less active in the colon, even though both were experiencing DNA damage.

“It’s possible that we have kind of a double whammy [in the colon]. You have this bacterium that suppresses DNA repair, at the same time that you have all this DNA damage happening in the tissue as a result of the immune response to the bacterium,” Dedon added.

The researchers also identified several previously unknown types of damage to DNA in mice and humans, one of which involves oxidation of guanine, a building block of DNA, to two new products, spiroiminodihydantoin and guanidinohydanotoin.

In future studies, the MIT team plans to investigate the mechanisms of cancer development in more detail, including looking at why cells experience an increase in some types of DNA damage but not others.

The study appeared in the online edition of Proceedings of the National Academy of Sciences.

ANI



First Published: Tuesday, June 12, 2012 - 16:18

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