Kineret halts organ damage in inflammatory genetic disorder
Washington: Kineret (anakinra), a medication approved for the treatment of rheumatoid arthritis, effectively blocks progression of organ damage in people with neonatal-onset multisystem inflammatory disease (NOMID), a new study has revealed.
This rare and debilitating genetic disorder causes persistent inflammation and ongoing tissue damage.
NOMID affects numerous organs and body systems, including the skin, joints, eyes, and central nervous system. The first sign of the disease is often a rash that develops within the first weeks of life. Other problems, including fever, meningitis, joint damage, vision and hearing loss, and mental retardation, can follow.
Kineret, one of a relatively new class of drugs known as biologic response modifiers or biologics, blocks the activity of interleukin-1 (IL-1), a protein made by cells of the immune system. IL-1 is overproduced in NOMID and a number of other diseases, leading to damaging inflammation.
Previous work by the same National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the National Institutes of Health, scientists showed that blocking IL-1 was effective in relieving symptoms of NOMID.
However, this is the first study to show that Kineret works over the long-term and, at higher doses, can also control damage that often results in vision and hearing loss, and brain lesions.
“Inflammation prolonged over many years will eventually cause irreversible damage and loss of function,” said lead author Dr. Raphaela Goldbach-Mansky of the NIAMS Translational Autoinflammatory Disease Section.
For example, inflammation of the cochlea — a tiny structure of the inner ear — was found to be responsible for hearing loss in people with NOMID.
Thinning of the optic nerve caused by inflammation-related pressure in the brain has been identified as a cause of vision loss.
“We knew we could effectively block inflammation in the inner ear and in the brain and eyes. The next step was to find out if we could sufficiently prevent the progression of hearing or vision loss,” said Goldbach-Mansky.
Study participants, who ranged in age from 10 months to 42 years, were treated with daily doses of Kineret based on body weight — 1 to 5 milligrams of Kineret per kilogram of body weight (1 to 5 mg/kg/day) — for at least 36 months and as long as 60 months.
Disease activity was monitored with blood tests to measure C-reactive protein, a marker for inflammation in the body, and by daily diaries kept by the patients or their parents.
The researchers also used sensitive MRI imaging methods to assess inflammation in the inner ear and brain.
Researchers found the initial Kineret doses used were insufficient to control organ inflammation, but by increasing the dose, they were
able to do so.
By preventing organ inflammation, scientists were able to preserve organ function in most patients. In addition, the scientists found ways to predict who is at greatest risk of hearing and vision loss.
These findings point to the importance of early diagnosis and treatment to keep organ damage from developing.
Because IL-1 is needed to fight infections, there has been concern that blocking it with high doses of Kineret might leave the body
vulnerable to infections.
But overall, the study drug was well tolerated. While Kineret is not a cure for NOMID — its effects last only as long as the drug is taken — the study offers hope for people with the disease.
“This study shows that treatment over five years is safe and effective, and can prevent organ damage,” Goldbach-Mansky added.
The study has been published online in Arthritis ‘n’ Rheumatism.
More from India
More from World
More from Sports
More from Entertaiment
- 'Maggi' under regulatory scanner for excess amount of lead, MSG
- When Subramanian Swamy shocked people at a wedding!
- Watch: Michelle Obama's 'Gimme Five' fitness video
- Mumbaikars join hands to save Pakistani teen with rare illness
- PM Modi speaks at Golden Jubilee celebrations of poet Dinkar’s works
- Mumbai: Diamond export company denies job to Muslim youth
- Mirage 2000 fighter jet landing was part of capability demonstration: IAF
- Vadodara: Policemen seen dancing with bar girls
- Coal scam: Naveen Jindal, Madhu Koda and others get bail
- DNA: IAF Mirage 2000 fighter plane lands successfully on Yamuna expressway
- One year of Modi govt: Arun Jaitley addresses press conference
- DNA: Osama documents show 'Indian brother in Madinah' financed al Qaeda
- ISIS executes Syrian fighter using anti-tank rocket launcher
- Zee Media Exclusive: Kangana, Madhavan talk about their film 'Tanu Weds Manu Returns'
- Woman robbed at gunpoint inside Hyderabad ATM
- CBSE Class 10 Results 2015 to be announced today?
- Check Jharkhand Board jac.nic.in: Class 12th Art Results 2015 declared
- Fawad Khan doesn’t want intimate scenes with Sonam Kapoor?
- We hire only non-Muslim candidates, diamond export firm tells Muslim youth
- Is MSG in 'Maggi' noodles harmful for you?
- Mumbai firm booked for denying Muslim MBA graduate job on religious grounds, probe ordered
- Jayalalithaa makes public appearance, meets Governor: As it happened
- New IPL rules could see Chennai Super Kings lose MS Dhoni
- `Piku` hits jackpot, does Rs 100 crore business worldwide
- Anurag Kashyap to bid goodbye to India, settle in 'cinema-friendly' France!
- IPL 2015, Qualifier 2, Chennai Super Kings vs Royal Challengers Bangalore: Preview
- Geelani's passport application incomplete, cannot be processed: MEA
- CBSE Class X Results 2015 to be announced today?
- Kerala Plus Two Results 2015 on keralaresults.nic.in
- Lalu Yadav invites Jitan Ram Manjhi for joint fight against BJP, JD(U) upset