Malaria vaccine`s effectiveness declines over a period of 4 years
Washington: A study by researchers from KEMRI-Wellcome Trust Research Programme and Oxford University in Kenya has shown that the efficacy of a malaria vaccine candidate, RTS,S, wanes over time and varies with exposure to the malaria parasite.
The findings will help to inform which populations are likely to benefit most from the vaccine candidate.
They also have important implications for the design of future clinical trials of this and other vaccine candidates and highlight the importance of long-term follow-up studies for assessing vaccine efficacy.
The study involved 447 children in Kilifi, Kenya, who had been part of an earlier phase II trial to assess the safety and efficacy of the vaccine candidate.
Of the 447 children, 320 completed four years of follow-up.
The analysis was designed to look at how well the vaccine candidate protects against malaria over time.
Initial results from larger ongoing phase III studies showed that the candidate RTS,S vaccine reduced malaria over 12 months of follow-up by approximately half in young children
The new findings on long-term follow-up of an earlier phase II study reveal that the vaccine efficacy dropped from 43.6 percent protection against malaria in the first year to zero by the fourth year after vaccination.
The study`s senior author, Dr Phillip Bejon (Research Fellow at the KEMRI-Wellcome Trust Research Programme and the Centre for Tropical Medicine, University of Oxford), said, "Despite the falling efficacy over time, there is still a clear benefit to the vaccine candidate. Many of the children will experience multiple episodes of clinical malaria infection, but overall we found that 65 cases of malaria were averted over the four-year period for every 100 children vaccinated. We now need to look at whether offering a vaccine booster can sustain efficacy for longer."
The study also shows that relative vaccine efficacy declines with increasing exposure to malaria, from 45.1 percent among children with below-average exposure to malaria to 15.9 percent among children with above-average exposure to malaria.
The relative efficacy describes the number of cases of malaria that were avoided by vaccination as a percentage of the total number of cases in that group because there were many more cases of malaria at higher exposure, the cases averted per 100 children vaccinated actually increased from 62 at below-average exposure to 78 at above-average exposure.
The study`s lead author, Dr Ally Olotu, a Wellcome Trust PhD student at the KEMRI-Wellcome Trust Research Programme and Oxford University said, "We need to consider whether relative efficacy or absolute number of cases averted is the more informative measure. In any case, these are important findings that will help to inform which populations are likely to benefit most from the vaccine."
"The ongoing phase III study will provide further insights to the vaccine`s efficacy in different settings of malaria exposure and includes an assessment of a booster dose to sustain efficacy over time," he said.
The study is published in the New England Journal of Medicine.
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