New discovery could lead to more effective flu drugs
Toronto: A discovery could spur a new generation of drugs that would be more effective against the flu virus than current drugs.
The new class of molecular compounds, developed by Simon Fraser University virologist Masahiro Niikura and his doctoral student Nicole Bance, will help develop drugs that the flu virus` strains can`t adapt to, and resist, as easily as Tamiflu, which is becoming less effective against the constantly mutating virus.
Their study reveals how to use their newly-discovered compounds to interrupt the enzyme neuraminidase`s facilitation of the flu`s spread, reports the journal Science Express.
Tamiflu and another flu drug, Relenza, focus on interrupting neuraminidase`s ability to help flu virus detach from an infected cell`s surface by digesting sialic acid, a sugar on the cell surface.
The virus uses the same sugar to stick to the cell while invading it. Once attached, influenza can invade the cell and replicate.
This is where the newly-discovered compounds come to the still-healthy cells` rescue. They clog up neuraminidase, stopping the enzyme from dissolving the sialic acid, which prevents the virus from escaping the infected cell and spreading, according to a Simon Fraser statement.
The new compounds are also more effective because they are water-soluble. "They reach the patient`s throat where the flu virus is replicating after being taken orally," says Niikura, associate professor.
"Influenza develops resistance to Replenza less frequently, but it`s not the drug of choice like Tamiflu because it`s not water-soluble and has to be taken as a nasal spray.
"Our new compounds are structurally more similar to sialic acid than Tamiflu. We expect this closer match will make it much more difficult for influenza to adapt to new drugs," adds Niikura.
Ultimately, the new compounds will buy scientists more time to develop new vaccines for emerging strains of influenza that are resistant to existing vaccines.
More from India
More from World
More from Sports
More from Entertaiment
- One year of Modi govt: PM promises to fulfil aspirations
- Watch: Mumbai cops find new secret agents in housewives!
- Hundreds die as heat wave continues in India
- 2G scam: Ex-TRAI chief alleges Manmohan Singh had warned him to cooperate
- Pranab Mukherjee defends Bofors scam, says it was just a media trial
- Salman Khan attends sister Arpita's wedding reception in Mandi
- Zee Media's mega survey on Modi govt
- Zee Media Exclusive: Vidya Balan chats about 'Hamari Adhuri Kahani'
- Para athlete Deepa Malik complains of callous service by Air India
- Smriti Irani visits Amethi, promises to pay insurance money to 25,000 women
- One year of Modi govt: Amit Shah addresses media
- I eat beef, can somebody stop me?: Kiren Rijiju hits back at Naqvi
- Delhi: Visually impaired boy scores 91.4% in CBSE 12th Board exams
- MP: 14-year-old boy works as bonded labour since 2009
- BBV: What challenges lie ahead of Modi govt?
- One year of NDA govt: PM Modi writes open letter to nation, promises to transform India
- Arpita-Aayush wedding reception: Salman Khan spreads love in Mandi, says `hum aapke hain`
- World optimistic about India: PM Narendra Modi on 1 year of NDA govt
- MSBSHSE Class 12th HSC results 2015 to be declared at 1pm tomorrow
- Bharatiya Janata Party lacks majority for Ram Temple, Article 370: Amit Shah
- Rahul Gandhi takes a dig at one year of Modi govt, wishes 'happy birthday' to 'suit-boot ki sarkar'
- CBSE Class 10 Board Result 2015 (cbse.nic.in, cbseresults.nic.in) postponed?
- AAP govt moves resolution against MHA notification: As it happened
- Check mahresult.nic.in for MSBSHSE Maharashtra Class 12 HSC Result 2015
- Maharashtra MSBSHSE HSC Result 2015 on mahresult.nic.in
- CBSE Class 10 Board Result 2015 to be announced on May 28
- Heatwave kills 90 more in Andhra, Telangana; toll crosses 800
- Gujjars adamant on holding talks in Bayana; rail tracks remain blocked
- CBSE 10th result to be declared tomorrow
- I was misquoted, says Kiren Rijiju on 'beef' remark