New drug may stop spread of breast cancer
London: Researchers have identified a new compound that completely halts the spread of metastatic breast cancer in mice.
The vast majority of deaths from cancer result from its progressive spread to vital organs such as the brain and lungs - a process known as metastasis.
In a recent series of studies researchers identified a previously unknown critical role for a potential cancer causing gene, Bcl3, in metastatic breast cancer.
"We showed that suppressing this gene reduced the spread of cancer by more than 80 per cent," said Dr Richard Clarkson from Cardiff University's European Cancer Stem Cell Research Institute.
"Our next goal was to then find a way to suppress Bcl3 pharmacologically. Despite great improvements in therapy of early stage breast cancer, the current therapeutic options for patients with late stage metastatic disease are limited.
"There is therefore a clear unmet clinical need to identify new drugs to reverse or at least to slow down disease progression," he added.
Clarkson and his team joined up with researchers Dr Andrea Brancale and Dr Andrew Westwell from the Cardiff University School of Pharmacy and Pharmaceutical Sciences, to develop small chemical inhibitors of the Bcl3 gene.
Computer aided modelling of how the Bcl3 gene functions inside the cell allowed the group to identify a pocket on the surface of Bcl3 essential for its function.
By screening a virtual compound library for chemicals that could fit inside this pocket, using state-of-the-art computer software, they identified a drug candidate that potently inhibits Bcl3.
The compound was then trialled on mice with metastatic disease. The resulting effect was that the drug completely inhibited the development of the mice's metastatic tumours.
Researchers are now working to conduct clinical trials of the compound. The aim is to develop a therapeutic agent capable of blocking metastatic disease in breast cancer and a variety of tumour types.
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