New strategy to prevent hearing loss discovered
Washington: The protein AMPK, which protects cells during a lack of energy, plays a role in protecting sensory cells in the inner ear from permanent damage and helps maintain hearing after extreme noise exposure, a new study has found.
According to researchers from Germany and Canada, AMPK also activates a channel protein in the cell membrane that allows potassium to leave the cell and thereby prevents permanent to the ears.
This information could lead to new strategies and therapies to prevent and treat trauma resulting from extreme noise, especially in people with AMPK gene variants that may make them more vulnerable to hearing loss.
“Future research on the basis of the present study may lead to the development of novel strategies preventing noise-induced hearing loss or accelerating recovery from acoustic trauma,” Florian Lang, a researcher involved in the work from the Department of Physiology at the University of Tübingen, in Tubingen, Germany, said.
To make this discovery, Lang and colleagues compared two groups of mice. The first group was normal and the second lacked the AMPK protein.
Hearing of the mice was tested by measuring sound-induced brain activity. All mice were exposed to well-defined noise causing an acoustic trauma and leading to hearing impairment.
Prior to noise exposure, the hearing ability was similar in normal mice and mice lacking AMPK. After exposure, the hearing of the normal mice mostly recovered after two weeks, but the recovery of hearing in AMPK-deficient mice remained significantly impaired.
The study has been published in the FASEB Journal.
Download the all new Zee News app for Android and iOS to stay up to date with latest headlines and news stories in Politics, Entertainment, Sports, Technology, Business and much more from India and around the world.
More from India
More from World
More from Sports
More from Entertaiment
- Karnataka, Madhya Pradesh bypoll results: As it happened on November 24
- Intolerance issue: When did ‘Incredible India’ become ‘Intolerant India’, Anupam Kher asks Aamir Khan
- Tirupati, Tirumala rains update: Temple remains open; pilgrims continue to pour in for darshan
- BJP's big poser to Aamir Khan: Is there any better neighbour for Muslims than a Hindu?
- Muslim leader Asaduddin Owaisi says Aamir Khan wrong in wanting to leave India