New therapeutic agents that may benefit blood cancer patients identified
Washington: Researchers including an Indian origin scientist have discovered new therapeutic targets and drugs that could benefit people with certain types of leukemia or blood cancer in future.
Dr Reuben Kapur, Ph.D., the Frieda and Albrecht Kipp Professor of Pediatrics at the Indiana University School of Medicine and a researcher at the Indiana University Melvin and Bren Simon Cancer Center, and colleagues discovered in pre-clinical and pharmacological models that cancer cells with a mutation in the KIT receptor-an oncogenic/cancerous form of the receptor-in mast cell leukemia and acute myeloid leukemia can be stopped.
According to Kapur, activating mutations of KIT receptors are almost always associated with a type of leukemia called mast cell leukemia. The mutations in the KIT receptor are found in about 90 percent of patients with this type of leukemia.
In addition, activating mutations of KIT are also exclusively associated with a subtype of acute myeloid leukemia known as core binding factor leukemia. When KIT is associated with these two types of leukemia, the survival rate for patients is profoundly reduced in comparison to patients who do not have this mutation.
Kapur said that his team identified two new targets in leukemic cells bearing this mutation, which when targeted or inhibited, cause leukemia cells to die.
The researchers discovered that the two targets are Rac GTPase and Pak (p21-activated kinase). In return, they designed a novel Rac inhibitor-EHop-016 -- that is considerably more potent than previously described inhibitors of Rac. They also demonstrated a novel role for Pak inhibition in leukemia using an existing Pak inhibitor.
The study has been published online in the Journal of Clinical Investigation.
More from India
More from World
More from Sports
More from Entertaiment
- Munich attack: 18-year-old German-Iranian gunman kills 9 at shopping mall
- DNA: Why are politicians and media ignoring the patriotic residents of Gurez Valley?
- DNA: Why are politicians and media ignoring the patriotic residents of Gurez Valley? Part II
- DNA: Why are politicians and media ignoring the patriotic residents of Gurez Valley? Part III
- DNA: Analyzing the real problems of patriotic Kashmir's residents
- Soon, Skype will not run on these Windows, Android phones
- Munich shooter was German-Iranian, motive `unclear`; likely sole shooter
- 'EgyptAir Flight 804 broke up in midair after a fire'
- Warrants issued in Turkey for arrest of 300 Presidential Guards
- Democrat Hilary Clinton picks Kaine as vice presidential running mate