New treatment for osteoporosis discovered

PTI| Last Updated: Nov 30, 2013, 09:47 AM IST

Melbourne: Researchers have discovered a promising new treatment for osteoporosis which involves a compound that boosts bone formation and can be easily delivered in water soluble form.

Researchers from the University of Sydney said the new treatment has shown very promising results in animal experiments.

The compound is called picolinic acid, a product derived of the essential amino acid tryptophan.

Lead researcher Professor Gustavo Duque said the odourless compound can be easily dissolved in water.

"This is a major step in the development of a completely new type of medication for osteoporosis. Instead of stopping bone destruction, our compound instead stimulates bone formation," he said.

"The product is easily dissolved in water, has a higher level of absorption and did not induce any side effects in the treated mice.

"When this medication was administered in the water of normal and menopausal mice, picolinic acid strongly and safely increased bone mass in normal mice and rescued bone from menopause-associated osteoporosis," he said.

Osteoporosis is a progressive bone disease that is characterised by a decrease in bone mass and density which can lead to an increased risk of fracture.

Duque said the team had patented the compound and will expand their trials to humans in the near future in a bid to address the increasing numbers of people developing the condition.

"Osteoporosis affects an estimated 300 million people worldwide. One in three women over 50 will experience osteoporotic fractures, as will one in five men," Duque said.

"Despite the current treatments available, by 2050, the worldwide incidence of hip fracture in men is projected to increase by 310 per cent and 240 per cent in women.

"This increase is explained by the low rate of diagnosis and treatment for osteoporosis, as well as some concerns about the potential side effects of the current treatments," Duque said.