Novel way blocks tumour growth into cancer
London: In pioneering research on models of human tumours in mice, researchers have successfully blocked metastasis - the strategy adopted by tumour cells to transform into an aggressive form of cancer.
According to researchers from Universite catholique de Louvain (UCL) in Belgium, blocking metastasis or even prevent their formation would be a giant step in the fight against cancer.
The researchers achieved this feat by studying mitochondria in tumour cells.
These organelles are considered the cells' powerhouse.
"When their functioning is altered, the mitochondria can promote cell migration, thus leading to the formation of metastasis," said professor Pierre Sonveaux from Universite catholique de Louvain's Institute of Experimental and Clinical Research (IREC).
Sonveaux's team examined the molecular mechanism responsible for the mitochondria's ability to promote metastasis.
They succeeded in showing that under certain conditions, the mitochondria produce more free radicals known as superoxide ions.
It is this overproduction of superoxide that leads to the formation of metastasis and, consequently, the growth of a tumour, they found.
"The production of superoxide by mitochondria can be blocked by very specific antioxidants," Sonveaux added.
These compounds turned out to be very efficient at blocking the migration of tumour cells and preventing the spontaneous formation of human tumour metastasis in mice, the study, published in the journal Cell Reports, said.
More from India
More from World
More from Sports
More from Entertaiment
- Vyapam Scam: IMA president Sudhir Tiwari fears life threat
- Vyapam Scam: Mystery over journalist Akshay Singh's death continues
- Jhansi police launches ‘Citizen Cop’ android app
- Panel discussion on RSS's 'Muslim Rashtriya Manch' first Iftaar party
- Kailash Vijayvargiya on Akshay Singh's death: Is a journalist bigger than me?
- Vyapam scam: MP medical college dean found dead in hotel, body sent for post-mortem
- Vyapam scam: Last rites of journalist Akshay Singh performed; MP CM assures of SIT probe
- Photographer captures International Space Station flying across moon
- PM Narendra Modi holds talks with Uzbek leader
- 'Selfie with daughter' controversy: Bollywood supports Shruti Seth