Obese mums-to-be have lower foetal growth restriction

Last Updated: Apr 28, 2012, 14:24 PM IST

Washington: Obesity during pregnancy makes women vulnerable to a multitude of challenges.

But according to a new study foetal growth restriction, or the poor growth of a baby while in the mother`s womb, is not one of them.

In fact, study authors from the University of Rochester Medical Center found that the incidence of foetal growth restriction was lower in obese women when compared to non-obese women.

Researchers, led by senior study author and high-risk pregnancy expert Loralei Thornburg, M.D., conducted the study because a wealth of data shows that obese women are at greater risk of foetal death or stillbirth.

Unfortunately, in the majority of cases, doctors don’t know why.

Thornburg’s team wanted to determine if foetal growth restriction – which increases the likelihood of stillbirth – might play a role.

She said that growth restriction may go undiagnosed in obese women because it can be difficult to get an accurate measure of mom’s belly size, which is a tool used to gauge the baby’s growth – or lack of growth.

“We wondered if the increased risk of stillbirth could be due to a high level of undiagnosed growth restriction – the idea being that if the physician doesn’t know that the baby is too small then they don’t know that mom and baby need additional monitoring, which is essential to prevent foetal death,” said Thornburg, an assistant professor in the Department of Obstetrics and Gynecology at the Medical Center whose research focuses on obesity in pregnancy.

The team, including lead study author and Maternal-Foetal Medicine Fellow Dzhamala Gilmandyar, M.D., found that growth restriction was significantly lower in obese and diabetic women; it was higher in women with
preeclampsia, or pregnancy-induced high blood pressure, and smokers – a finding in line with past research.

Of the babies that had growth restriction, they determined how many moms were given an accurate diagnosis before birth and found that the rate was the same for obese and non-obese women, suggesting that missed diagnoses are not a major problem in obese pregnancies.

“Our results defeat the idea that undiagnosed growth restriction is behind increased rates of foetal death in obese women,” noted Thornburg.

Many obese women also have diabetes, which could influence the risk of foetal death, but more research is needed to understand whether or not that is the case.

While the cause of stillbirths in obese women remains elusive, Thornburg said “One thing we do know is that we are not just dealing with obesity in pregnancy anymore. We are seeing a real increase in extreme obesity, which may represent a different condition altogether, so we need to look at moderate obesity compared to severe, morbid obesity.”

Thornburg and Gilmandyar reviewed birth record data from more than 16,000 women who delivered at the Medical Center between 2000 and 2010.

Obesity was defined as having a pre-pregnancy body mass index or BMI of 30 or greater and growth restriction was defined as being below the tenth percentile of expected birth weight for gestational age.

After taking into account the effects of diabetes, high blood pressure and tobacco use, growth restriction remained lower in obese women (8.5 percent) compared to non-obese women (nearly 10 percent).

“While our study shows that obesity by itself may not be a risk factor for growth restriction, it is still important to closely monitor women who also have high blood pressure or who are smokers, because these are established risk factors for growth restriction,” said Gilmandyar, who is completing her second year as a fellow at the Medical Center.

ANI