Salt’s real role in high blood pressure revealed
Washington: Researchers have debunked the widely-believed concept that hypertension, or high blood pressure, is the result of excess salt causing an increased blood volume, exerting extra pressure on the arteries.Their research found that excess salt stimulates the sympathetic nervous system to produce adrenalin, causing artery constriction and hypertension.
The research was led by Irene Gavras, MD, and Haralambos Gavras, MD, both professors of medicine at Boston University School of Medicine.
“The purpose of this paper is to correct an erroneous concept that has prevailed for many years, even though scientific evidence has mounted against it,” said Irene Gavras, who is also a physician in Boston Medical Center`s Hypertension practice.
The term “volume-expanded hypertension” implies that excess salt leads to the retention of extra fluid within the arterial circulatory system, causing an increase in blood volume and added pressure on the arterial walls.
However, research has shown that conditions characterized by the expansion of blood volume from other causes, such as the secretion of antidiuretic hormone or the excessive elevation of blood sugar, do not cause a rise in blood pressure because the extra fluid is accommodated by the distention of capillaries and veins.
“The body’s circulatory system is a highly flexible vascular system with the capacity to open up new capillaries and distend veins in order to accommodate increased fluid volume,” said Irene Gavras, MD, professor of medicine at BUSM.
Through a review of numerous studies, the researchers demonstrated that the mechanism of hypertension resulting from the excessive consumption and retention of salt stimulates the sympathetic nervous system in the brain to increase adrenaline production.
The increased adrenalin being circulated throughout the body causes the arteries to constrict, which results in resistance to blood flow and a decrease in circulatory volume.
The over-activation of the sympathetic nervous system – part of the autonomic nervous system that helps maintain the body``s homeostasis – has been recognized clinically as a characteristic of hypertension that accompanies renal failure, which is the most typical example of elevated blood pressure from excessive salt retention.Diuretics, which remove excess salt, are widely used to treat this type of hypertension.
However, this study provides convincing evidence that the sympathetic nervous system should be the focus of further investigations into treatments for hypertension.
The implication of our findings shows that the optimal treatment for hypertension, for cases associated with renal failure, should not only include diuretics but also the use of drugs that block the central sympathetic nervous system,” concluded Irene Gavras.
The study was published online in the Journal of Hypertension.
More from India
More from World
More from Sports
More from Entertaiment
- Afzal Guru row: JNU Students' Union president Kanhaiya Kumar arrested
- DNA: Analysis on actions taken against students protesting at JNU
- DNA: Analysis on actions taken against students protesting at JNU - Part II
- Watch: How students at JNU showcased anti-India spirit! - Part II
- DNA: Gravitational waves detected, proving Einstein right!
- Kidnappers treated me well, gave me money to reach home: Snapdeal executive Dipti Sarna's 36-hour ordeal
- Why Modi never spoke on issues like beef or Muzaffarnagar, asks Manmohan Singh
- Valentine week: Celebrate 'Kiss Day' with these unique kisses!
- 4th ODI: South Africa vs England - Hosts win game by solitary wicket to level series
- JNUSU prez Kanhaiya Kumar sent to 3-day police custody over Afzal Guru row, says being targeted for defeating ABVP in polls