Washington: Bugs that normally inhabit the skin may actually protect the body from infection, shows a study.
By the virtue of being the largest organ of the body, the skin represents a major site of interaction with microbes outside.
Although immune cells in the skin protect against harmful organisms, until now it has not been known if the millions of naturally occurring bugs on the skin, collectively known as the skin microbiota (skin flora), also have a beneficial role.
Using mouse models, the National Institute of Health (NIH) observed that such skin bugs contribute to protective immunity by interacting with the immune cells in the skin, the journal Science reported.
The investigators colonized germ-free mice (mice bred with no naturally occurring microbes in the gut or skin) with the human skin commensal Staphylococcus epidermidis, according to a NIH statement.
The team observed that colonizing the mice with this one species of good bugs enabled an immune cell in the mouse skin to produce a cell-signalling molecule needed to protect against harmful microbes.
Researchers subsequently infected both colonised and non-colonised germ-free mice with a parasite.
Mice that were not colonised with the bacteria did not mount an effective immune response to the parasite; mice that were colonised did.
The study was led by investigators in the labs of Yasmine Belkaid, at the National Institute of Allergy and Infectious Diseases, in collaboration with Julie Segre, at the National Human Genome Research Institute, and Giorgio Trinchieri and Heidi Kong, at the National Cancer Institute. All three Institutes are NIH components.