Washington: Men who have sleep problems, including difficulty falling asleep and staying asleep, may be at twice the risk for prostate cancer, a new study has warned.
"Sleep problems are very common in modern society and can have adverse health consequences," said Lara G Sigurdardottir, at the University of Iceland in Reykjavik.
"Women with sleep disruption have consistently been reported to be at an increased risk for breast cancer, but less is known about the potential role of sleep problems in prostate cancer," she said.
The team investigated the role of sleep in influencing prostate cancer risk.
The researchers followed 2,102 men from the prospective Age, Gene/Environment Susceptibility-Reykjavik study, which involved an established, population-based cohort of 2,425 men aged 67 to 96.
Upon enrolment into the study, the participants answered four questions about sleep disruption: whether they took medications to sleep, had trouble falling asleep, woke up during nights with difficulty going back to sleep or woke up early in the morning with difficulty going back to sleep.
Among the participants, 8.7 per cent and 5.7 per cent reported severe and very severe sleep problems, respectively. None of the participants had prostate cancer at study entry.
The researchers followed the participants for five years, and during this period, 6.4 per cent were diagnosed with prostate cancer.
After the researchers adjusted for age, they found that compared with men who reported no problems with sleeping, the risk for prostate cancer increased proportionately with reported severity of problems falling and staying asleep, from 1.6-fold to 2.1-fold.
Further, the association was stronger for advanced prostate cancer than for overall prostate cancer, with more than a three-fold increase in risk for advanced prostate cancer associated with "very severe" sleep problems.
To rule out the possibility that the problems with sleeping were because of undiagnosed prostate cancer or an enlarged prostate, the researchers reanalysed the data after excluding men with symptoms of sleep disturbance that might be indicative of nocturia (waking up during the night to urinate). The results remained unchanged.
According to Sigurdardottir, these data should be confirmed with a larger cohort with longer observation times.
"Prostate cancer is one of the leading public health concerns for men and sleep problems are quite common," she said.
"If our results are confirmed with further studies, sleep may become a potential target for intervention to reduce the risk for prostate cancer," she added.
The study was published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.