Washington: Researchers have discovered that smoking can have a lasting legacy, and one well-established risk factor for asthma is having a mother who smoked during her pregnancy.
When animal mothers are exposed to nicotine during pregnancy-a proxy for smoking-their grandchildren were also at an increased risk of asthma, even though they were never exposed to nicotine themselves.
Wondering if this dangerous heritage might extend even farther down the family line, Virender K. Rehan and his colleagues at Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed) exposed pregnant rats to nicotine.
They then tested an additional generation-the mothers' great-grand-rats-for signs of asthma .
Their results suggest that this group of rats is also at an increased risk of this condition, bearing the brunt of nicotine exposure three generations in the past.
The study is published in the American Journal of Physiology-Lung Cellular and Molecular Physiology, published by the American Physiological Society.