Washington: Researchers have developed a new biodegradable graft that helps regenerate coronary arteries within 90 days of bypass surgeries, leaving no trace of itself in the body.Designed by principal investigator professor Yadong Wang and his team from the University of Pittsburgh Swanson School of Engineering, the graft fully harnesses the body`s regenerative capacity."The host site, the artery in this case, is an excellent source of cells and provides a very efficient growth environment. This is what inspired us to skip the cell culture altogether and create these cell-free synthetic grafts," said Wang, the journal Nature Medicine reportsThe team, which included former Pitts postdoctoral associate Wei Wu and bioengineering doctoral student Robert Allen, designed the graft with three properties in mind, according to a Pittsburgh statement.First, they chose a graft material - an elastic polymer called PGS - that is resorbed quickly by the body. Then, they examined graft porosity and selected parameters that allow immediate cell infiltration.Wang`s team borrowed a procedure developed by another team of Pitt researchers - David Vorp, professor of bioengineering and surgery, and William R. Wagner, professor of surgery, bioengineering and chemical engineering - wrapping the vascular graft with a fibrous sheath to trap the cells.
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