Washington: A key molecule identified as IQGAP1 can suppress growth of liver tumours by altering the micro-environment against cancer cells, reveals a new finding.The finding offers new insight into cancer metastasis, the ability of a tumour to spread from its primary site to distant organs such as the brain, lung or liver. The discovery paves the way to newer therapies for preventing or treating liver metastases, the major cause of death from cancer."Tumour cells are intelligent - they talk to the cells in their surroundings to change the way they behave and make the environment supportive of cancer growth," said senior study author Ningling Kang, biochemist and molecular biologist at Mayo Clinic Cancer Centre, the Journal of Clinical Investigation reports."If we can disrupt the communication between the tumour cells and the tumour micro-environment, we can prevent tumour growth or metastasis in the liver," Kang was quoted as saying in a Mayo Clinic statement.
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