London: Prostate cancers spread more quickly and are more often fatal in men who have inherited a faulty gene, a new study has warned. The team at The Institute of Cancer Research, London, and The Royal Marsden National Health Service (NHS) Foundation Trust found men who develop prostate cancer after inheriting a faulty BRCA2 gene need immediate surgery or radiotherapy rather than being placed under surveillance, as their disease is more aggressive than other types. The research could challenge current NHS guidelines for prostate cancer, under which BRCA2 mutation carriers are offered the same treatment options as non-carriers. The new study, published in the Journal of the Clinical Oncology, is the largest to compare prostate cancer patients with and without BRCA mutations. "It is clear from our study that prostate cancers linked to inheritance of the BRCA2 cancer gene are more deadly than other types," said senior author Professor Ros Eeles, Professor of Oncogenetics at The Institute of Cancer Research (ICR) and Honorary Consultant in Clinical Oncology at The Royal Marsden.
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