Washington: Scientists have discovered a potential strategy for developing treatments to stem the disease process in Alzheimer`s disease. It`s based on unclogging removal of toxic debris that accumulates in patients` brains, by blocking activity of a little-known regulator protein called CD33."Too much CD33 activity appears to promote late-onset Alzheimer`s by preventing support cells from clearing out toxic plaques, key risk factors for the disease," explained Rudolph Tanzi, Ph.D., of Massachusetts General Hospital and Harvard University, a grantee of the NIH`s National Institute of Mental Health (NIMH) and National Institute on Aging (NIA). "Future medications that impede CD33 activity in the brain might help prevent or treat the disorder," Tanzi added.Variation in the CD33 gene turned up as one of four prime suspects in the largest genome-wide dragnet of Alzheimer`s-affected families, reported by Tanzi and colleagues in 2008. The gene was known to make a protein that regulates the immune system, but its function in the brain remained elusive. To discover how it might contribute to Alzheimer`s, the researchers brought to bear human genetics, biochemistry and human brain tissue, mouse and cell-based experiments.They found over-expression of CD33 in support cells, called microglia, in postmortem brains from patients who had late-onset Alzheimer`s disease, the most common form of the illness. The more CD33 protein on the cell surface of microglia, the more beta-amyloid protein and plaques - damaging debris - had accumulated in their brains.
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