Washington: Your survival post chemotherapy may depend on your genes, scientists say.An eight gene `signature` can predict length of relapse-free survival in cancer patients after chemotherapy, according to a new research.Researchers from Academia Sinica and the National Taiwan University College of Medicine first identified genes that were involved in cellular invasion, a property of many cancer cells, using the National Cancer Institute`s 60 human cancer cell line panel (NCI-60).Comparing the pattern of activation of each of these genes in different cell lines with how these cell lines responded to 99 different anti-cancer drugs, helped narrow down the list of genes to just those which could potentially influence the outcome of chemotherapy."Our study found eight genes which were involved in invasion, and the relative activation of these genes correlated to chemotherapy outcome, including the receptor for growth factor EGF," Prof Ker-Chau Li, from Academia Sinica and UCLA, said.
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