Washington: Scientists have identified a previously unknown genetic variant that is associated with an increased risk of coronary heart disease (CHD) in type 2 diabetic patients.This discovery has the potential to lead to the development of new treatments for CHD in diabetic patients.CHD is the leading cause of morbidity and mortality among diabetic patients. Diabetic individuals have a two- to threefold increased risk for CHD and two- to fourfold higher CHD morbidity and mortality rates.Scientists in Genetics and Epidemiology at Joslin were interested in finding out whether there were genetic determinants of CHD specific to diabetic patients.In collaboration with colleagues from the Harvard School of Public Health and research institutes in Italy, they conducted genome-wide association analyses of 1,517 type 2 diabetic patients with CHD and 2,671 type 2 diabetic subjects without CHD.
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