London: US researchers analysing genetic influences in attention deficit/hyperactivity disorder (ADHD) have found alterations in specific genes involved in important brain signalling pathways.According to paediatric researchers at The Children’s Hospital of Philadelphia, the new study raises the possibility that drugs acting on those pathways might offer a new treatment option for patients with ADHD who have those gene variants.“At least 10 percent of the ADHD patients in our sample have these particular genetic variants,” Hakon Hakonarson, the study leader, said.“The genes involved affect neurotransmitter systems in the brain that have been implicated in ADHD, and we now have a genetic explanation for this link that applies to a subset of children with the disorder,” he said.ADHD is a common but complex neuropsychiatric disorder, estimated to occur in as many as 7 percent of school-age children and in a smaller percentage of adults.
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