Washington: Researchers from MIT`s Koch Institute of Integrative Cancer Research including two of Indian origin have presented a novel approach to developing a dengue therapy using mutated antibodies.According to a study by the International Research Consortium on Dengue Risk Assessment, Management and Surveillance, up to 390 million people are infected with the dengue virus each year. For most people the mosquito-borne virus causes flulike symptoms, including fever, headache and joint pain. But for some, particularly children, the virus can develop into the far more serious dengue hemorrhagic fever, causing severe blood loss and even death.Despite the threat posed by the disease, developing a vaccine against dengue has so far proved challenging, according to Ram Sasisekharan, the Alfred H. Caspary Professor of Biological Engineering at MIT. That`s because dengue is not one virus but four different viruses, or serotypes, each of which must be neutralized by the vaccine.
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