Washington: Researchers are one step closer in preventing death related to heart diseases, thanks to their discovery of a key molecule in an unexpected place in heart cells - mitochondria, tiny energy factories that house the controls capable of setting off cells` self-destruct sequence.The study by a team of scientists at Temple University School of Medicine`s (TUSM) is the first to identify the molecule, an enzyme known as GRK2 (G protein-coupled receptor kinase 2), in mitochondria.It was led by Walter J. Koch, Ph.D., Professor and Chairman of the Department of Pharmacology at TUSM, and Director of the Center for Translational Medicine at TUSM."We have known that GRK2 is involved in the pathological development of certain heart diseases, such as chronic heart failure, and that its increased activity can lead to the death of heart cells. But its mechanism for the latter was unclear," Koch said.In addition, while the enzyme was known to be present in elevated levels in the hearts of patients with heart failure, the reasons for its rise were not fully understood.Normally, GRK2 hangs out near the plasma membrane of heart cells, where it turns off certain signals transferred from the blood to the tissue.But the researchers at Temple found that it moves to mitochondria in response to two classic features of heart disease, ischemic insult and ensuing oxidative stress.
Moeen warned over pro-Gaza Test wristbands
ISIS opens `marriage bureau` in Syria
Farmers should get better technology: PM
Delhi shame: Class 10th student gang-raped in Uttam Nagar at gun point