Washington: Researchers used human tissue samples to discover that those with osteoarthritis have a signature epigenetic change, DNA methylation, which is responsible for switching on and off a gene that produces a destructive enzyme called MMP13.MMP13 is known to play a role in the destruction of joint cartilage, making it and the epigenetic changes that lead to its increased levels, prime targets for osteoarthritis drug development.In addition to offering a new epigenetic path toward a cure for osteoarthritis, this research also helps show how epigenetic changes play a role in diseases outside of cancer.
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