Washington: Overexpression of a protein can disrupt vital recycling processes in neurons leading to development of Parkinson`s disease – a neurodegenerative movement disorder.Researchers at the University of California, San Diego School of Medicine found that overexpression of the alpha-synuclein protein appears to disrupt vital recycling processes in neurons.It starts with the terminal extensions of neurons, working its way back to the cells` center, with the potential consequence of progressive degeneration and eventual cell death."This is an important new insight. I don`t think anybody realised just how big a role alpha-synuclein played in managing the retrieval of worn-out proteins from synapses and the role of alterations in this process in development of PD," said principal investigator Mark H Ellisman.
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