London: A research team including an Indian origin has identified a new gene associated with the amyloid plaque deposits found in Alzheimer`s disease patients.In their study that combine genetic data with brain imaging, they have not only identified the APOE gene-long associated with development of Alzheimer`s-but also uncovered an association with a second gene, called BCHE.The study, led by scientists at the Indiana University School of Medicine, is believed to be the first genome-wide association study of plaque deposits using a specialized PET scan tracer that binds to amyloid.The research also is believed to be the first to implicate variations in the BCHE gene in plaque deposits visualized in living individuals who have been diagnosed with Alzheimer`s disease or are at-risk for developing the disease. The enzyme coded by the BCHE gene has previously been studied in post-mortem brain tissue and is known to be found in plaques.
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