London: Researchers have identified the genetic variations that are believed to cause osteoporosis.They found that women with a higher proportion of genetic variations associated with osteoporosis have a more than 50 percent increased fracture risk.Osteoporosis is a common and a devastating age-related disease. About 50 percent of all who have a hip fracture after age 80 die within one year from the time of injury.The consequences of osteoporosis are therefore well-known, but the causes of the disease are largely unknown.In a groundbreaking international study, which is led partially from the Sahlgrenska Academy at the University of Gothenburg, Sweden, researchers have now succeeded in identifying a total of 56 genetic regions that control bone density in human beings.Fourteen of these genetic variants increase the risk of fractures, the study has found.“This is the first time anyone has identified the genetic variants that are so strongly associated with an increased risk of fracture,” said Claes Ohlsson, a professor at the Sahlgrenska Academy.An international consortium, which also involves researchers from Umea University, Uppsala University and Malmpo University, is behind the study.
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