Washington: After studied genetic data of more than 11,000 people, researchers have found six genes that predispose people to the most common subtype of migraine without aura.Four of these genes are new and two of them confirm previous findings.The new genes identified in this study provide further evidence for the hypothesis that dysregulation of molecules important in transmitting signals between brain neurons contribute to migraine. Two of the genes support the hypothesis of a possible role of blood vessels and thus disturbances in blood flow.The researchers carried out what is known as a genome-wide association study (GWAS) to zoom in on genome variants that could increase susceptibility to migraine; they compared genomes of 4800 migraine patients with more than 7000 non-migraine individuals. The International Headache Genetics Consortium consisting of leading migraine researches from Europe and Australia performed the project.This was the third report on genes predisposing people to common forms of migraine, but the first one on the most common migraine subtype.“The study establishes for the first time a specific gene that contributes to this common disease,” said Professor Aarno Palotie at FIMM and the Wellcome Trust Sanger Institute, the chair of the International Headache Genetics Consortium.
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