Washington: A new method of analyzing whole genome sequences of TB has helped identify 39 new genes linked to the disease`s elevated drug resistance.The new data suggests that acquiring resistance is a multistep process, perhaps requiring low-level resistance mutations prior to the ones that are well known.The findings also suggest that some of these new genes are involved in resistance that may confer `global` resistance traits, helping strains become resistant to a group of antibiotics rather than just one or a single class.To find the novel drug-resistance genes, Maha Farhat, HMS instructor in medicine and assistant physician at Massachusetts General Hospital,, Megan Murray, HMS professor of global health and social medicine and collaborators adapted tools from evolutionary biology known as `phylo genetics.`The team examined the whole genomes of 116 newly sequenced and 7 previously sequenced strains of TB.
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