Washington: A new study has suggested that gut bacteria are an integral part of the body`s complex system for maintaining a stable blood pressure.Using mice models, researchers at The Johns Hopkins University and Yale University have discovered that a specialized receptor, normally found in the nose, is also in blood vessels throughout the body, sensing small molecules created by microbes that line mammalian intestines, and responding to these molecules by increasing blood pressure."The contribution that gut microbes apparently make to blood pressure regulation and human health is a surprise. There is still much to learn about this mechanism, but we now know some of the players and how they interact," said Jennifer Pluznick, Ph.D., assistant professor of physiology at the Johns Hopkins University School of Medicine.Pluznick said that several years ago, thanks to a "happy coincidence," she found - in the kidney - some of the same odor-sensing proteins that give the nose its powers.Focusing on one of those proteins, olfactory receptor 78 (Olfr78), her team specifically located it in the major branches of the kidney`s artery and in the smaller arterioles that lead into the kidney`s filtering structures. Olfr78 also turned up in the walls of small blood vessels throughout the body, she said, particularly in the heart, diaphragm, skeletal muscle and skin.
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