Washington: The enhanced aggressiveness of recurrent tumours may be due to changes in the body`s immune response, scientists led by an Indian-origin researcher have claimed.The traditional view of recurrent tumours is that they are resistant to therapy because they`ve acquired additional genetic mutations that make them more aggressive and impervious to drugs.Now, researchers at the Perelman School of Medicine at the University of Pennsylvania found in an animal model that the increased aggression of recurrent tumours could be due to changes in the body`s immune response."Typically when a patient has a tumour recurrence, their oncologist treats them, much like they treated them for the primary tumour - with drugs aimed at the tumour cells themselves," said senior study author Sunil Singhal, assistant professor of Surgery and director, Thoracic Surgery Research Laboratory at the Perelman School of Medicine.
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