Washington: Low birth weight is an important environmental factor contributing to the risk of autism spectrum disorder (ASD), a new study has found.Although the genetic basis of autism is now well established, a growing body of research also suggests that environmental factors may play a role in this serious developmental disorder affecting nearly one in 100 children.“Our study of discordant twins -- twin pairs in which only one twin was affected by ASD -- found birth weight to be a very strong predictor of autism spectrum disorder,” Molly Losh, the lead author of the study from Northwestern University, said.Prior twin studies have shown that when one identical twin had ASD, the other twin was much more likely to have ASD than not.“Because identical twins share virtually 100 percent of their genes, this is strong evidence for the role of genetics in autism,” Losh said.“Yet it is not 100 percent the case that ASD affects both identical twins in a twin pair.“That only one twin is affected by ASD in some identical twin pairs suggests that environmental factors may play a role either independently or in interaction with autism risk genes.“And because autism is a developmental disorder impacting brain development early on, it suggests that prenatal and perinatal environmental factors may be of particular importance,” she said.
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