Washington: Researchers have found that the gene p53, which is the most commonly mutated gene in cancer, has a novel role in the development of ischemic stroke.p53 is dubbed the “guardian of the genome” because it blocks cells with damaged DNA from propagating and eventually becoming cancerous.However, new research led by Ute M. Moll, M.D., Professor of Pathology at Stony Brook University School of Medicine, and colleagues, uncovers a novel role for p53 beyond cancer in the development of ischemic stroke.The team identified an unexpected critical function of p53 in activating necrosis, an irreversible form of tissue death, triggered during oxidative stress and ischemia.Ischemia-associated oxidative damage leads to irreversible necrosis which is a major cause of catastrophic tissue loss.Elucidating its signalling mechanism is of paramount importance. p53 is a central cellular stress sensor that responds to multiple insults including oxidative stress and is known to orchestrate apoptotic and autophagic types of cell death.
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