Washington: A team of researchers have made a breakthrough that may help provide more answers about precise molecular mechanisms by which insulin regulates glucose uptake in fat and muscle cells.The conserved phospholipid enzyme, PIKfyve, was discovered by Assia Shisheva, Ph.D., professor of physiology in Wayne State University`s School of Medicine, lab in 1999.Based on studies in cultured cells, the lab has implicated PIKfyve in the insulin-regulated glucose transport activation, which led to the development of a unique mouse model with PIKfyve ablation, or removal, in muscle (MPlfKO), the tissue responsible for the majority of postprandial glucose disposal.
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