Washington: University of Missouri researchers have created a new drug that is 10 times more potent than current cancer-fighting drugs.In a new study, MU medicinal chemists have taken an existing drug that is being developed for use in fighting certain types of cancer, added a special structure to it, and created a more potent, efficient weapon against cancer.“Over the past decade, we have seen an increasing interest in using carboranes in drug design,” said Mark W. Lee Jr., assistant professor of chemistry in College of Arts and Science.“Carboranes are clusters of three elements — boron, carbon and hydrogen. Carboranes don’t fight cancer directly, but they aid in the ability of a drug to bind more tightly to its target, creating a more potent mechanism for destroying the cancer cells,” he explained.In the study, Lee and his research team used carboranes to build new drugs designed to shut off a cancer cell’s energy production, which is vital for the cell’s survival.All cells produce energy through complex, multi-step processes. The key to an effective drug is targeting the process that cancer cells depend on more than healthy cells.By increasing the binding strength of a drug, a smaller dose is required, minimizing side effects and increasing the effectiveness of the therapy. With carboranes, Lee found that the drug is able to bind 10 times more powerfully.
Zohra Sehgal, the grand old diva of Indian cinema
Heavy rains disrupt normal life in Mumbai
Varanasi: Three held for capturing Ganga aarti
Congress to oppose Nripendra Mishra`s appointment as Principal Secy to PM