Washington: Scientists, including one of Indian-origin, have discovered a new molecular pathway responsible for causing heart failure and showed that a prototype drug blocks this pathway to protect the heart from damage.In contrast to standard therapies for heart failure, the compound called JQ1 works directly within the cell`s command centre, or nucleus, to prevent damaging stress responses."Our discovery heralds a brand new class of drugs which work within the cell nucleus and offers promise to millions suffering from this common and lethal disease," said Saptarsi Haldar, senior author on the paper, assistant professor of medicine at Case Western Reserve and cardiologist at University Hospitals Case Medical Center.The researchers focused on the cell`s periphery to the nucleus - the very place that unleashes sweeping damage-control responses which, if left unchecked, ultimately destroy the heart.They found that a new family of genes, called BET bromodomains, cause heart failure because they drive hyperactive stress responses in the nucleus.Prior research linking BET bromodomains to cancer prompted the laboratory of James Bradner, the paper`s senior author and a researcher at the Dana-Farber Cancer Institute, to develop a direct-acting BET inhibitor, called JQ1.
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