Washington: Lean type 2 diabetes patients have a larger genetic disposition to the disease as compared to their obese counterparts, a new study has proved.Type 2 diabetes is popularly associated with obesity and a sedentary lifestyle. However, just as there are obese people without type 2 diabetes, there are lean people with the disease.It has long been hypothesised that type 2 diabetes in lean people is more “genetically driven”.The study, from a research team led by the Peninsula College of Medicine and Dentistry (PCMD), University of Exeter, has also identified a new genetic factor associated only with lean diabetes sufferers.Using genetic data from genome-wide association studies, the research team tested genetic markers across the genome in approximately 5,000 lean patients with type 2 diabetes, 13,000 obese patients with the disease and 75,000 healthy controls.The team found differences in genetic enrichment between lean and obese cases, which support the hypothesis that lean diabetes sufferers have a greater genetic predisposition to the disease.
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